Handguns in general are not the "sweet spot" of 3D2A. Consumer printers and the materials they can handle just can't produce strong enough parts in the sizes that make sense for most handguns. So when it comes to handguns you basically have two reasonable choices:
- Any of the single-shot 22LR designs. Building one of the Harlet/Harlot/Gambino/Cabfare or their derivatives is sort of a rite of passage into 3D2A. These are complete DIY builds and will teach you good fundamentals that will help you on more advanced projects.
- A "parts kit" build where you take all the parts from a mass-produced handgun like the Glock and print your own frame. I'm personally not a fan due to the relatively high cost (cheap parts dramatically reduce reliability) and the limited knowledge/experience gained. But if you just want a range toy you can mag-dump into trash, this will get you there.
Avoid the NAG (Not-A-Glock) permanently. Avoid the NULL22 and other NAG derivatives until you have experience with a simpler full DIY build. Same for the revolver designs.
Assume your first build is just that -- your first, but not your last. Keep it cheap and modest and use it as a stepping stone to reach more ambitious goals.
Unless you're content using 22LR, fully DIY 3D printed self-loading handguns just aren't currently viable. Even those in 22LR are challenging builds with questionable reliability. If you want a reliable DIY semi-auto, you're going to have to settle for PCC/PDW platforms. Even with those, the barrel is a bit of a barrier. DIY is possible, but you'll have to master the electro-chemical machining (ECM) process. Barrel liner builds are only realistic for 22LR due to the enormous pressures involved in center-fire handgun ammunition. But note that in the US, commercial barrels aren't regulated. Any local gun shop will be happy to sell you one in a cash transaction with no paper trail.
That said, relying on a 3D printed firearm for personal protection is questionable at best. Unless you're legally restricted, pick up a law enforcement trade-in 9mm handgun or a pump-action shotgun (both can be had for just a little more than the cost of a 3D2A DIY build) and call it a day. Think of 3D printed guns much as you would a "curio and relic" antique. Cool to own and maybe safe to use it at the range, but not something you bet your life on. I love my Urutau, but it's had one OOB that destroyed half the gun and the rebuild is now on its third firing pin. Lately it's been running good and will shoot a full mag without a failure, but I also know that the chance of something breaking or wearing out on the next shot is orders of magnitude higher than even many antiques.